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EC number: 500-258-9 | CAS number: 74775-06-7 1 - 2.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Based on the information available it can be concluded that the substance is not hazardous following short-term expsoure via the dermal route and the substance has a NOAEL of 1,000 mg/kg bw/day.
An experiment for short-term repeated dose (28-day) oral toxicity has been waived as the dermal route is considered to be the most relevant route of administration for PPG-2 myristyl ether propionate and sufficient information is available to determine dermal toxicity following repeated dose. Equally, as the substance has a low vapour pressure and, therefore, volatility, it is not expected that human exposure via inhalation during use / production will occur. A short-term repeated dose (28-day) toxicity test for inhalation has subsequently been waived.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- a short-term toxicity study by the oral route does not need to be conducted because an appropriate dermal study is available and dermal is the most appropriate route of administration as based on the provided thorough and rigorous exposure assessment
Reference
Repeated dose toxicity: dermal - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- other: Endpoint Assessment Report: Short-term Repeated-dose Toxicity via the Dermal Route
- Adequacy of study:
- key study
- Study period:
- March 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An extensive literature search was undertaken to identify studies on the toxicity of PPG-2 myristyl ether propionate following a repeated exposure via the dermal route.
- GLP compliance:
- no
- Key result
- Remarks on result:
- other: Quantative results not determined
- Key result
- Critical effects observed:
- no
- Conclusions:
- Based on the information available it can be concluded that the substance is not hazardous following short-term expsoure via the dermal route and has a NOAEL of 1,000 mg/kg bw/day.
- Executive summary:
A reliable study performed by Bernard et al. (1998) was identified in the literature. This study included examination of the reproductive organs of treated animals allowing to investigate the effects of the substance to fertility. It is concluded that PPG-2 myristyl ether propionate is not hazardous following a short-term exposure via the dermal route and has a NOAEL of 1,000 mg/kg bw/d. This is supported by the historical uses of the substance is cosmetics and personal care products.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Species:
- rat
Repeated dose toxicity: dermal - local effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- other: Endpoint Assessment Report: Short-term Repeated-dose Toxicity via the Dermal Route
- Adequacy of study:
- key study
- Study period:
- March 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An extensive literature search was undertaken to identify studies on the toxicity of PPG-2 myristyl ether propionate following a repeated exposure via the dermal route.
- GLP compliance:
- no
- Key result
- Remarks on result:
- other: Quantative results not determined
- Key result
- Critical effects observed:
- no
- Conclusions:
- Based on the information available it can be concluded that the substance is not hazardous following short-term expsoure via the dermal route and has a NOAEL of 1,000 mg/kg bw/day.
- Executive summary:
A reliable study performed by Bernard et al. (1998) was identified in the literature. This study included examination of the reproductive organs of treated animals allowing to investigate the effects of the substance to fertility. It is concluded that PPG-2 myristyl ether propionate is not hazardous following a short-term exposure via the dermal route and has a NOAEL of 1,000 mg/kg bw/d. This is supported by the historical uses of the substance is cosmetics and personal care products.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/cm²
- Species:
- rat
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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