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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From September 02, 2017 to September 19, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
EU Regulation (EC) 440/2008, Annex Part A test A4
Deviations:
not specified
GLP compliance:
not specified
Type of method:
isoteniscope
Key result
Test no.:
#1
Temp.:
ca. 20 °C
Vapour pressure:
< 100 Pa
Key result
Test no.:
#2
Temp.:
ca. 20 °C
Vapour pressure:
< 100 Pa
Key result
Test no.:
#3
Temp.:
ca. 20 °C
Vapour pressure:
< 100 Pa

Full test results:

 

Deionised Water

(reference)

Test substance

Test 1

2320 Pa

< 100 Pa

Test 2

2333 Pa

< 100 Pa

Test 3

2333 Pa

< 100 Pa

Average

2329 Pa

< 100 Pa

Conclusions:
Under the study conditions, the vapour pressure of the test substance was determined to be <100 Pa.
Executive summary:

A study was conducted to determine the vapour pressure of the test substance according to the OECD Guideline 104 and EU Method A4 , the isoteniscope method, in compliance with GLP. Under the study conditions, the vapour pressure of the test substance was determined to be <100 Pa (Chilworth, 2017).

Description of key information

The vapour pressure of the test substance was determined using the isoteniscope method according to OECD Guideline 104 and EU Method A.4 (Chilworth, 2017) as well using QSAR models of EPI Suite and T.E.S.T. (US EPA, 2018).

Key value for chemical safety assessment

Vapour pressure:
1.15 Pa
at the temperature of:
25 °C

Additional information

- Experimental VP: <100 Pa at 20 °C (using isoteniscope method);

- QSAR based VP: Using EPI Suite v.4.11, the VP values for the individual constituents ranged from 0.0744 to 0.186 Pa, leading to a weighted average value of 0.102 Pa at 25°C; the estimates are considered to be reliable with restrictions, as they do not completely fall within of the applicability domain. Using US EPA T.E.S.T v.4.2.1, the VP values ranged from 0.824 to 2.18 Pa, leading to a weighted average value of 1.15 Pa at 25°C; the estimates for the test substance are considered to be reliable, as they fall within of the applicability domain.

Overall, based on the above information, the test substance can be considered to have low volatility potential. However, in absence of a specific value from the experimental study, the higher weighted average QSAR based VP value of 1.15 Pa has been considered further for hazard/risk assessment.