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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From January 29th to February 02nd, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
adopted July 27, 1995
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Water solubility:
68.82 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
8
Details on results:
The water solubility of test item was determined to be 68.82 ± 4.01 g/l (95 % confidence interval) at 20 °C ± 0.5 °C using the flask method for the performance of the main test.
The repeatability of the determination was < 15 % and thus within the range required by the guidelines.

Sampling time  Measured concentration of test item, g/l Measured pH
Test vessels Mean
after 24 hours 65.97 70.60 8
72.60 8
73.23 8
after 48 hours 65.33 67.45 8
69.70 8
67.33 8
after 72 hours 66.65 68.41 8
69.64 8
68.93 8
Mean with confidence interval (95 %) - 68.82 ± 4.01 -
RSD % - 2 -
Conclusions:
68.82 ± 4.01 g/l at 20 °C and pH 8
Executive summary:

The water solubility of the test item was determined by flask mehod, follwing the procedures outlined into the OECD guideline 105. About 6.9 g test item was weighed into stoppered Erlenmeyer flasks (nine parallels) according to the estimated solubility based on the Preliminary Test. After the addition of 25 ml ultrapure water, the flasks were agitated at 30 °C. After one day, three of the vessels were removed and re-equilibrated at 20 °C for 24 hours. The content of the vessel was then centrifuged at 20 °C and the concentration in the clear aqueous phase was determined by HPLC. The other flasks were treated similarly after initial equilibration at 30 °C for two and three days, respectively. The samples were diluted before the analysis (two parallel dilutions). The pH of each sample was recorded.

The water solubility of test item was determined to be 68.82 ± 4.01 g/l (95 % confidence interval) at 20 ± 0.5 °C using the flask method for the performance of the main test. The repeatability of the determination was < 15 % and thus within the range required by the guidelines.

Conclusion

68.82 ± 4.01 g/l at 20 °C and pH 8

Description of key information

68.82 ± 4.01 g/l at 20 °C and pH 8

Key value for chemical safety assessment

Water solubility:
68.82 g/L
at the temperature of:
20 °C

Additional information

OECD 105 - flask method