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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report Date:
1974

Materials and methods

GLP compliance:
no
Remarks:
pre GLP
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Sex:
male

Administration / exposure

Vehicle:
DMSO
Details on dermal exposure:
Gauze pads were soakedwith test item and fixed on the depilated dorsal skin of rats.
The treated skin areas were not washed off afterwards.
Duration of exposure:
4 hours
Doses:
5000 mg/kg

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
LD50 > 5000 mg/kg
Executive summary:

The dermal acute toxicity potential of the test item was assayed in rats. Gauze pads were soaked with test item and fixed on the depilated dorsal skin of rats. The bendage was removed after 4 hours and the treated skin areas were not washed off. Unfortunately, only a brief sheet of results is available, thus details about test procedures, results and test conditions are lacking. Therefore, a reliability cannot be assigned. The LD50 was indicated to be greater than 5000 mg/kg.