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EC number: 249-172-0 | CAS number: 28706-33-4
The acute lethal toxicity of test item to Poecilia reticulata (Guppy) was investigated under static exposure conditions over a period of 96 h. The only applied nominal test concentration was 100 mg/l. No chemical analysis of the test substance concentration was conducted. At the nominal concentration of 100 mg/l none of total of seven fish died after 96 h of exposure. No mortality was also observed in the blank control. Other toxic effects than mortality, e.g. loss of coordination, hypo- or hyperactivity and swimming on the back, were not observed. The no-observed-effect concentration (NOEC) was ≥ 100 mg/. 100 % mortality (LC100) could not be detected. Based on the binominal theory, the absence of morlality provides at least 99 % confidence that the LC50 is greater than the applied nominal test concentration of 100 mg/l.
LD50 (96h) > 100 mg/l (nominal)
Not harmful/toxic to fish for short-term exposure (LD50 (96h) > 100 mg/l, nominal).
Only an old non-GLP experiment is available on Direct Orange 118. The test was conducted on rainbow trout. Unfortunately, only a brief sheet of results is available, thus details about test method, procedures and test conditions are lacking. Therefore, a reliability cannot be assigned. The LC0 after 48 hours was indicated to be 800 ppm wt/vol; the LC50 value was indicated to be 1200 ppm wt/vol; the LC100 was indicated to be 2000 ppm wt/vol.
In order to confirm the short-term toxicity potential of Direct Oragne 118 to fish, the available data on structural analogous Similar Substance 01 have also been taken into account. The read across approach can be considered as reliable and suitable for the purpose; details and explanations are detailed in the report attached to the IUCLID section 13.
The acute lethal toxicity of test item to guppy was investigated under static exposure conditions over a period of 96 h. The only applied nominal test concentration was 100 mg/l. None of total of seven fish died after 96 h of exposure and no mortality was also observed in the blank control. Other toxic effects than mortality, e.g. loss of coordination, hypo- or hyperactivity and swimming on the back, were not observed.
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