2-hydroxyethyl [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl] carbonate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1993-12-06 to 1994-04-20

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

1992

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

signed 1994-03-16

Type of method:

flask method

Key result

Water solubility:

148 mg/L

Conc. based on:

test mat.

Incubation duration:

>= 48 - <= 96 h

Temp.:

20 °C

pH:

>= 6.2 - <= 6.3

Remarks on result:

other: loading of aqueous phase: ~ 1 g/L

RESULTS

The preliminary test determined the water solubility to be approximately 0.18 g/L. The mean peak heights relating to the standard and sample solutions are detailed below:

Solution	Mean peak height
Standard 1.00 x 10³ mg/L	2.082 x 10^5
Standard 1.01 x 10³ mg/L	1.979 x 10^5
Sample 1	1.488 x 10^5
Sample 2	1.497 x 10^5
Sample 3	1.489 x 10^5

Sample number	Time shaken at 30 °C [h]	Time held at 20 °C [h]	Concentration [g/L]	Solution pH
1	24	24	0.147	6.3
2	48	24	0.148	6.2
3	72	24	0.147	6.3

Mean = 0.148 g/L

Range = 0.147 to 0.148 g/L

Conclusions:

According to Council Directive 92/69/EEC A.6, the water solubility of the test item is 148 mg/L (20 °C ± 0.5 °C, pH 6.3). The test substance is moderately soluble.

Description of key information

The water solubility of the test substance is 148 mg/L (20 °C ± 0.5 °C, pH 6.3).

Key value for chemical safety assessment

Water solubility:

148 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the substance was performed in accordance to Council Directive 92/69/EEC A.6 under GLP. Based on preliminary results the flask method was applied. The substance was analytically verified using GC.