Registration Dossier

Diss Factsheets

Administrative data

Description of key information

The key study for skin sensitisation (Hüls 1998) conducted according to OECD Test Guidelines 406 (Buehler test) and GLP, found 3-trimethoxysilylpropane-1-thiol sensitising to the skin of Dunkin-Hartley guinea-pigs.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

3-Trimethoxysilylpropane-1-thiol was tested in a traditional Buehler skin sensitisation study, to GLP. The test and control animals showed normal body weight gains throughout the study. No clinical signs of systemic effects were observed in any of the animals during the observation period. There were no skin reactions following induction Phase I. Following Phases II and III there was moderate to severe skin reactions. The control animals treated with the vehicle only, did not show any irritation after all three inductions. Following the challenge application there were skin reactions in eight animals: 30 hours post-application the animals had moderate to intense erythema and swelling; at 54 hours patchy to intense erythema and swelling. All 12 other test, and all control animals did not show any skin reactions 30 -54 hours after treatment. Therefore the the study authors concluded that 3-trimethoxysilylpropane-1-thiol is a skin sensitiser.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available data, 3-trimethoxysilylpropane-1-thiol is classified as sensitising, Skin Sensitisation Category 1B; H317: May cause an allergic skin reaction, according to Regulation (EC) 1272/2008.