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Toxicity to microorganisms

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Description of key information

Toxicity to microorganisms: 3-hour ASRI EC50 463 mg/l and EC10 32.6 mg/l (EC guideline 118/133 (1988)). The EC50 and EC10 are equivalent to 364 mg/l and 26 mg/l when expressed in terms of the silanol hydrolysis product.

Key value for chemical safety assessment

EC50 for microorganisms:
364 mg/L
EC10 or NOEC for microorganisms:
26 mg/L

Additional information

A 3-hour ASRI EC50 value of 463 mg/l and EC10 value of 32.6 mg/l were determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP. The results may be expressed in terms of concentration of the hydrolysis product, 3-(trihydroxysilyl)propanethiol, by applying a molecular weight correction: (MW of silanol=154.26 / MW of parent=196.34) * 463 = 364 mg/l.

Methanol does not have adverse effects on microorganisms (OECD 2004).