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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

long-term toxicity to aquatic invertebrates
Type of information:
experimental study planned (based on read-across)
Study period:
After approval by ECHA
Justification for type of information:
Please see the RAAF report for ecotoxicity attached in the IUCLID EPSR, Section 13 of IUCLID and Annex 4 of the CSR for justification of read-across.
according to guideline
OECD Guideline 211 (Daphnia magna Reproduction Test)
Principles of method if other than guideline:
Not applicable

Description of key information

Key value for chemical safety assessment

Additional information

No measured long-term toxicity to aquatic invertebrates data are available with the registered substance, 3-(trimethoxysilyl)propane-1-thiol (CAS 4420-74-0, EC No. 224-588-5).

A long-term Daphnia reproduction test in accordance with OECD TG 211 is being conducted with the analogue substance 3-(triethoxysilyl)propanethiol (CAS 14814-09-6, EC No. 238-883-1). Once the results are available, the Daphnia reproduction test with 3-(triethoxysilyl)propanethiol (CAS 14814-09-6) will be read across to the registered substance to fulfil the REACH Annex IX requirements.

The chemical safety assessment and PNECs will be revised once the long-term data are available.

3-(Trimethoxysilyl)propane-1-thiol and 3-(triethoxysilyl)propanethiol are structural analogues, the difference being that the registered substance contains methyl groups, whereas the analogue substance contains ethyl groups. Although this effects the rate of hydrolysis, both substances will hydrolyse and share a common silanol hydrolysis product, 3-(trihydroxysilyl)propanethiol. Both parent substances and silanol hydrolysis product contain a thiol side chain which is understood to drive the toxicity of the substance.

Justification for read-across is discussed in the RAAF report for ecotoxicity, attached in Section 13 of IUCLID and Annex 4 of the CSR.