Registration Dossier
Registration Dossier
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EC number: 224-588-5 | CAS number: 4420-74-0
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study planned (based on read-across)
- Study period:
- After approval by ECHA
- Justification for type of information:
- Please see the RAAF report for ecotoxicity attached in the IUCLID EPSR, Section 13 of IUCLID and Annex 4 of the CSR for justification of read-across.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Principles of method if other than guideline:
- Not applicable
Reference
Description of key information
Key value for chemical safety assessment
Additional information
No measured long-term toxicity to aquatic invertebrates data are available with the registered substance, 3-(trimethoxysilyl)propane-1-thiol (CAS 4420-74-0, EC No. 224-588-5).
A long-term Daphnia reproduction test in accordance with OECD TG 211 is being conducted with the analogue substance 3-(triethoxysilyl)propanethiol (CAS 14814-09-6, EC No. 238-883-1). Once the results are available, the Daphnia reproduction test with 3-(triethoxysilyl)propanethiol (CAS 14814-09-6) will be read across to the registered substance to fulfil the REACH Annex IX requirements.
The chemical safety assessment and PNECs will be revised once the long-term data are available.
3-(Trimethoxysilyl)propane-1-thiol and 3-(triethoxysilyl)propanethiol are structural analogues, the difference being that the registered substance contains methyl groups, whereas the analogue substance contains ethyl groups. Although this effects the rate of hydrolysis, both substances will hydrolyse and share a common silanol hydrolysis product, 3-(trihydroxysilyl)propanethiol. Both parent substances and silanol hydrolysis product contain a thiol side chain which is understood to drive the toxicity of the substance.
Justification for read-across is discussed in the RAAF report for ecotoxicity, attached in Section 13 of IUCLID and Annex 4 of the CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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