Registration Dossier
Registration Dossier
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EC number: 252-279-5 | CAS number: 34907-26-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Read-across
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- From read-across report
- Justification for type of information:
- See attached for read-across supporting information.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Results aquired form a JMPR evaluation - guideline followed is not specified in the report.
- GLP compliance:
- not specified
- Remarks:
- Data from collection/ handbook, no informaiton on completion date or compliace is available.
Test material
- Reference substance name:
- 2,6-dichloro-4-nitroaniline
- EC Number:
- 202-746-4
- EC Name:
- 2,6-dichloro-4-nitroaniline
- Cas Number:
- 99-30-9
- Molecular formula:
- C6H4Cl2N2O2
- IUPAC Name:
- 2,6-dichloro-4-nitroaniline
- Test material form:
- solid
- Details on test material:
- Molecule for read-across studies
Constituent 1
- Specific details on test material used for the study:
- Read-across to 2,6-dichloro-4-nitroaniline (JMPR evaluation)
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: abraded or unabraided
- Vehicle:
- water
- Amount / concentration applied:
- 500 mg per site (Raczniak & Wood, 1980b) or after repeated daily applications of 10 mg dry material or 0.1 ml of 10% aqueous suspension to the abraded or unabraded skin of albino rabbits over five days (Boots Pure Drug Co., 1962)
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Final result from read-across molecule
- Basis:
- other: Final result from read-across molecule
- Time point:
- other: Final result from read-across molecule
- Reversibility:
- other: Not irritating (JMPR evaluation)
- Remarks on result:
- no indication of irritation
- Remarks:
- Not irritating (JMPR evaluation)
Any other information on results incl. tables
Technical-grade dicloran (purity, 96%) was not irritating to the intact or abraded skin of male or female New Zealand white rabbits at a concentration of 500 mg per site (Raczniak & Wood, 1980b) or after repeated daily applications of 10 mg dry material or 0.1 ml of 10% aqueous suspension to the abraded or unabraded skin of albino rabbits over five days (Boots Pure Drug Co., 1962).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The compound 2,6-dichloro-4-nitroaniline was found to be not irritating, and therefore has no irritation classification under CLP (1272/2008)
- Executive summary:
The compound 2,6-dichloro-4-nitroaniline was found to be not irritating, and therefore has no irritation classification under CLP (1272/2008)
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