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Registration Dossier
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EC number: 223-672-9 | CAS number: 4016-14-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: publication
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Sufficiently documented publication, scientifically reasonable method, testing performed on the registered substance itself.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicology of Glycidol and Some Glycidyl Ethers
- Author:
- Hine HC, Kodama JK, Wellington JS, Dunlap MK, Anderson HH
- Year:
- 1 956
- Bibliographic source:
- AMA Archives of Industrial Health. (Chicago, IL) 14,250,1956
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- conducted prior to GLP implementation
Test material
- Reference substance name:
- Isopropyl glycidyl ether
- IUPAC Name:
- Isopropyl glycidyl ether
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Isopropyl glycidyl ether
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: California Albino or New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: rabbitry at Point Reyes, Calif., or Gilroy laboratory, Calif.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated second eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- no information given on wash-out after instillation
- Observation period (in vivo):
- at least 48 h
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
SCORING SYSTEM: Draize
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: mean after 1, 24, 48 h
- Score:
- 40
- Reversibility:
- fully reversible
- Remarks on result:
- other: Scoring according to Draize (Draize JH: Procedures for the Appraisal of the Toxicity of Chemicals in Food, Drugs, and Cosmetics: VIII. Dermal Toxicity, Food, Drug, & Cos Law . 10:722, 1955)
Applicant's summary and conclusion
- Interpretation of results:
- other: moderately irritating (criteria used for interpretation of results: Draize scoring)
- Conclusions:
- The studied was conducted scientifically reasonable with sufficient documentation similar to OECD 405, it was assessed with Klimisch 2. Hence, the results are sufficiently reliable to assess the eye irritating properties of isopropyl glycidyl ether in rabbits. With an irritation score of 40, the substance is considered as moderate irritant according to Draize.
- Executive summary:
In a primary eye irritation study similar to OECD 405, 0.1 mL of unchanged Isopropyl glycidyl ether was instilled into the eye of male California Albino or New Zealand White rabbits. Animals then were observed for at least 48 h. Irritation was scored by the method of Draize.
In this study, Isopropyl glycidyl ether is a moderate eye irritant.
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