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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
other: publication
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available - Only secondary literature

Data source

Reference
Reference Type:
publication
Title:
Propane, 1,2-epoxy-3-isopropoxy-
Author:
Canadian Centre for Occupational Health and Safety
Year:
2010
Bibliographic source:
Registry of Toxic Effects of Chemical Substances (RTECS®); http://ccinfoweb.ccohs.ca/rtecs/search.html; query date : July 2010

Materials and methods

Principles of method if other than guideline:
database data, no information is given on test method
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-epoxypropyl isopropyl ether
EC Number:
223-672-9
EC Name:
2,3-epoxypropyl isopropyl ether
Cas Number:
4016-14-2
Molecular formula:
C6H12O2
IUPAC Name:
2-[(propan-2-yloxy)methyl]oxirane
Test material form:
not specified
Details on test material:
- Name of test material : Propane, 1,2-epoxy-3-isopropoxy-
- RTECS Number : TZ3500000
- Synonyms/Trade Names : ((1-Methylethoxy)methyl)oxirane , (Isopropoxymethyl)oxirane , 1,2-Epoxy-3-isopropoxypropane , 2,3-Epoxypropyl isopropyl ether , 3-Isopropyloxypropylene oxide , Glycidyl isopropyl ether , IGE , Isopropyl epoxypropyl ether , Isopropyl glycidyl ether , Isopropyl glycidyl ether , NCI-C56439 ; Oxirane, ((1-methylethoxy)methyl)-

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No details available

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
No details available
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
Dose Data : 1100 ppm/8H
No. of animals per sex per dose:
No details available
Control animals:
not specified
Details on study design:
No details available
Statistics:
No details available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
1 100 ppm
Based on:
not specified
Remarks on result:
other: Reference : AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume (issue)/page/year: 14,250,1956
Mortality:
No details available
Clinical signs:
other: No details available
Body weight:
No details available
Gross pathology:
No details available
Other findings:
Toxic Effects :
Lungs, Thorax, or Respiration - other changes
Liver - other changes

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Executive summary:

For the substance propane,1,2-epoxy-3-isopropoxy- a LC50 of 1100 ppm in the rat (sex not specified) is reported (Reference :AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume (issue)/page/year: 14,250,1956). The following toxic effects were additionally reported :

-Lungs, Thorax, or Respiration : other changes

-Liver : other changes

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