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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: publication
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available - Only secondary literature

Data source

Reference
Reference Type:
publication
Title:
Propane, 1,2-epoxy-3-isopropoxy-
Author:
Canadian Centre for Occupational Health and Safety
Year:
2010
Bibliographic source:
Registry of Toxic Effects of Chemical Substances (RTECS®); http://ccinfoweb.ccohs.ca/rtecs/search.html; query date : July 2010

Materials and methods

Principles of method if other than guideline:
database data, no information is given on test method
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-epoxypropyl isopropyl ether
EC Number:
223-672-9
EC Name:
2,3-epoxypropyl isopropyl ether
Cas Number:
4016-14-2
Molecular formula:
C6H12O2
IUPAC Name:
2-[(propan-2-yloxy)methyl]oxirane
Test material form:
not specified
Details on test material:
- Name of test material : Propane, 1,2-epoxy-3-isopropoxy-
- RTECS Number : TZ3500000
- Synonyms/Trade Names : ((1-Methylethoxy)methyl)oxirane , (Isopropoxymethyl)oxirane , 1,2-Epoxy-3-isopropoxypropane , 2,3-Epoxypropyl isopropyl ether , 3-Isopropyloxypropylene oxide , Glycidyl isopropyl ether , IGE , Isopropyl epoxypropyl ether , Isopropyl glycidyl ether , Isopropyl glycidyl ether , NCI-C56439 ; Oxirane, ((1-methylethoxy)methyl)-

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No further details available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No further details available
Doses:
No details available
No. of animals per sex per dose:
No details available
Control animals:
not specified
Details on study design:
No details available
Statistics:
No details available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 200 mg/kg bw
Based on:
not specified
Remarks on result:
other: Reference : AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume (issue)/page/year: 14,250,1956
Mortality:
No details available
Clinical signs:
other: No details available
Gross pathology:
No details available
Other findings:
Toxic Effects :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia

Applicant's summary and conclusion

Interpretation of results:
other: EU-GHS criteria not met
Executive summary:

For the substance propane,1,2-epoxy-3-isopropoxy- a LD50 of 4200 mg/kg in the rat (sex not specified) is reported(Reference :AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume (issue)/page/year: 14,250,1956). The following toxic effects were additionally reported :

-Brain and Coverings : recordings from specific areas of CNS

-Behavioral : somnolence (general depressed activity)

-Behavioral : ataxia