Registration Dossier
Registration Dossier
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EC number: 223-672-9 | CAS number: 4016-14-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: publication
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available - Only secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Propane, 1,2-epoxy-3-isopropoxy-
- Author:
- Canadian Centre for Occupational Health and Safety
- Year:
- 2 010
- Bibliographic source:
- Registry of Toxic Effects of Chemical Substances (RTECS®); http://ccinfoweb.ccohs.ca/rtecs/search.html; query date : July 2010
Materials and methods
- Principles of method if other than guideline:
- database data, no information is given on test method
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- 2,3-epoxypropyl isopropyl ether
- EC Number:
- 223-672-9
- EC Name:
- 2,3-epoxypropyl isopropyl ether
- Cas Number:
- 4016-14-2
- Molecular formula:
- C6H12O2
- IUPAC Name:
- 2-[(propan-2-yloxy)methyl]oxirane
- Test material form:
- not specified
- Details on test material:
- - Name of test material : Propane, 1,2-epoxy-3-isopropoxy-
- RTECS Number : TZ3500000
- Synonyms/Trade Names : ((1-Methylethoxy)methyl)oxirane , (Isopropoxymethyl)oxirane , 1,2-Epoxy-3-isopropoxypropane , 2,3-Epoxypropyl isopropyl ether , 3-Isopropyloxypropylene oxide , Glycidyl isopropyl ether , IGE , Isopropyl epoxypropyl ether , Isopropyl glycidyl ether , Isopropyl glycidyl ether , NCI-C56439 ; Oxirane, ((1-methylethoxy)methyl)-
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No further details available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No further details available
- Doses:
- No details available
- No. of animals per sex per dose:
- No details available
- Control animals:
- not specified
- Details on study design:
- No details available
- Statistics:
- No details available
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 200 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: Reference : AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume (issue)/page/year: 14,250,1956
- Mortality:
- No details available
- Clinical signs:
- other: No details available
- Gross pathology:
- No details available
- Other findings:
- Toxic Effects :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Applicant's summary and conclusion
- Interpretation of results:
- other: EU-GHS criteria not met
- Executive summary:
For the substance propane,1,2-epoxy-3-isopropoxy- a LD50 of 4200 mg/kg in the rat (sex not specified) is reported(Reference :AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume (issue)/page/year: 14,250,1956). The following toxic effects were additionally reported :
-Brain and Coverings : recordings from specific areas of CNS
-Behavioral : somnolence (general depressed activity)
-Behavioral : ataxia
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