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Toxicity to microorganisms

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Description of key information

Toxicity to microorganisms: 3h NOEC = 10 – 100 mg/L, 3h EC50 > 1000 mg/L, activated sewage sludge, based on respiration inhibition, OECD 209, static, GLP

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L
EC10 or NOEC for microorganisms:
10 mg/L

Additional information

There is a valid, well-documented GLP OECD 209 guideline study without relevant deviations on the 2,3-epoxypropyl isopropyl ether itself available, assessed with Klimisch 1. In this study, the following values were determined: 3h NOEC, EC10, EC20 = 10 – 100 mg/L, 3h EC50, EC80 > 1000 mg/L. The results can be considered as sufficiently reliable to assess the toxicity of 2,3-epoxypropyl isopropyl ether to microorganisms. Due to limitations of the IUCLID entry field, the EC50 and NOEC values will be stated as 10 mg/L resp. 1000 mg/L, are however very likely much higher.

With regard to the CLP Regulation 1272/2008, the results do not trigger classification of the test item as hazardous to the environment, as it isn't part of the classification criteria. In addition, it should be considered as harmless to the aquatic environment.

The database is of high quality, and the tonnage-driven data requirements under REACH are fully met, hence, no data gap was identified.

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