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Diss Factsheets
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EC number: 257-446-6 | CAS number: 51818-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- For details and justification of read-across please refer to the report attached in section 13 of IUCLID.
- Reason / purpose for cross-reference:
- read-across source
- Preliminary studies:
- No additional data.
- Details on absorption:
- Not applicable.
- Details on distribution in tissues:
- Not applicable.
- Details on excretion:
- Bulk activity was found in the feces and urine. Expired air contained less that 0.5% of the dose. The rate of excretion pattern seems consistent in all cases. Activity in both urine and feces falls off rapidly and indicate that further significant activity will not be forthcoming. The expired air samples indicate a peak rate of excretion around 12 hours and probably before. Representative fat, muscle, and blood samples showed specific activities near the measurable limit of 0.003% of the dose per gram. Of all tissues examined, the gastrointestinal tract showed the greatest specific activity. Total retained by the stomach was 0.02% of dose.
- Metabolites identified:
- not measured
- Details on metabolites:
- Not applicable.
- Conclusions:
- In conclusion, no bioaccumulation potential based on study results.
- Executive summary:
In this study, rats were fed 100 mg/kg bw/day of neodecanoic acid for 5 days and followed by a pulse of C-14 labeled neodecanoic acid and assessed every 24 hours for 3 days to determine the distribution and excretion. It was found that under the conditions of the experiment, 70-80% of the administered activity could be accounted for. Excretion in the urine may expect to range from 50-60% while that in the feces will vary from 40-50%. In any case, the total of these two will be at least 98%. The excretion rate falls off rapidly such that less than 1% of dose is expected past 72 hours. Expired air reaches a peak rate somewhere around 12 hours or earlier. The total carcass, exclusive of organs, retains less than 1% of the recovered dose. Intestines had the greatest specific activity and contribute as much as 1% of total dose. Analysis by thin layer chromatography shows that the bulk of excreted activity is either the original free acid or a material which is readily converted to the acid upon mild hydrolysis.
Reference
Description of key information
No data on the toxicokinetic behavior of the target substance, Neodecanoic acid, iron salt, were available. Therefore, toxicokinetic data from the dissociation product Neodecanoic acid is described. For details and justification of read-across please refer to the report attached in section 13 of IUCLID.
Based on the study results, Neodecanoic acid was bioavailable and was equally excreted via urine and feces. There were no signs for a bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No data on the toxicokinetic behavior of the target substance, Neodecanoic acid, iron salt, were available. Therefore, toxicokinetic data from the dissociation product Neodecanoic acid is described. For details and justification of read-across please refer to the report attached in section 13 of IUCLID.
In a toxicokinetik study, rats were fed 100 mg/kg bw/day of neodecanoic acid for 5 days and followed by a pulse of C-14 labeled Neodecanoic acid and assessed every 24 hours for 3 days to determine the distribution and excretion. It was found that under the conditions of the experiment, 70-80% of the administered activity could be accounted for. Excretion in the urine may expect to range from 50-60% while that in the feces will vary from 40-50%. In any case, the total of these two will be at least 98%. The excretion rate falls off rapidly such that less than 1% of dose is expected past 72 hours. Expired air reaches a peak rate somewhere around 12 hours or earlier. The total carcass, exclusive of organs, retains less than 1% of the recovered dose. Intestines had the greatest specific activity and contribute as much as 1% of total dose. Analysis by thin layer chromatography shows that the bulk of excreted activity is either the original free acid or a material which is readily converted to the acid upon mild hydrolysis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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