Registration Dossier
Registration Dossier
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EC number: 246-377-7 | CAS number: 24636-31-5
Endpoint summary
Administrative data
Description of key information
There are no data for skin and eye irritation/corrosion for 3-(chlorodimethylsilyl)propyl methacrylate. However, based on the fact that this substance is a chlorosilane, generating hydrogen chloride in the presence of moisture, it is expected to be corrosive. Therefore, in accordance with Column 2 of REACH Annex VIII, the irritation studies (required in Section 8.1.1 and 8.2.1) do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
3-(Chlorodimethylsilyl)propyl methacrylate hydrolyses very rapidly in contact with water and moist air, releasing hydrochloric acid (HCl). Although no reliable in vivo irritation/corrosion studies are available, severe skin, eye and respiratory damage can be expected due to release of hydrochloric acid. This is consistent with reliable measured data for other chlorosilanes.
Justification for classification or non-classification
3-(Chlorodimethylsilyl)propyl methacrylate is classified Skin Corr. 1A with hazard statement H314 ‘Causes severe skin burns and eye damage’ according to Regulation (EC) No 1272/2008.
There are no experimental data for skin or eye irritation/corrosion. 3-(Chlorodimethylsilyl)propyl methacrylate hydrolyses very rapidly in contact with water and moist air, releasing hydrochloric acid (HCl). Although no reliable in vivo irritation/corrosion studies are available, severe skin, eye and respiratory damage can be expected due to release of hydrochloric acid. This is consistent with reliable measured data for other chlorosilanes.
There are no experimental data for respiratory tract irritation but the additional hazard statement EUH071 ‘corrosive to the respiratory tract' (1272/2008/EC) is proposed in accordance with anticipated respiratory tract damage due to the hydrolysis product hydrochloric acid generated by chlorosilanes on contact with moisture.
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