Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Reported 19Jan2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
not specified
GLP compliance:
no
Other quality assurance:
other: ISO9001
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Reference substance name:
602-259-0
Cas Number:
12222-74-1
IUPAC Name:
602-259-0
Test material form:
solid: particulate/powder
Details on test material:
Test material from Sensient UK, various batches, see individual endpoint for specifics.
Specific details on test material used for the study:
DBN
INT000101 01330111101

Study design

Analytical method:
photometric method

Results and discussion

Partition coefficient
Key result
Type:
Pow
Partition coefficient:
10.39
Temp.:
20 °C
pH:
7
Details on results:
In a separating funnel 100ml of distilled water was added followed by 100 ml of octan-1-ol, this was
then shaken and left to settle for 10 minutes. 0.0352g of sample was added to the separating funnel,
this was shaken for 1 minute. The solution was then left overnight to allow the 2 phases to separate.
The next day the phases were separated into 2 100 ml volumetric flasks. These solutions were then
measured on the spectrophotometer using the relevant solvent as a blank.
Abs in octan-1-ol 0.321 @634nm (20 fold dilution required to get the abs in range)
Abs in water 0.618 @552nm

6.42/0.618 = 10.39

Applicant's summary and conclusion

Conclusions:
The Pow was experimentally determined to be 10.39 in a lab with a constant temperature of 20°C.
Executive summary:

The Pow was experimentally determined to be 10.39 in a lab with a constant temperature of 20°C.