Registration Dossier
Registration Dossier
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EC number: 201-317-9 | CAS number: 81-04-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study with limited information on test material, test animals, study design and clinical examination.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- limited information on test material, test animals, study design and clinical examination, exposure period too long, no guideline compliant application area
- GLP compliance:
- no
Test material
- Reference substance name:
- Naphthalene-1,5-disulphonic acid
- EC Number:
- 201-317-9
- EC Name:
- Naphthalene-1,5-disulphonic acid
- Cas Number:
- 81-04-9
- Molecular formula:
- C10H8O6S2
- IUPAC Name:
- naphthalene-1,5-disulfonic acid
- Test material form:
- solid: crystalline
- Details on test material:
- Unspecified test material
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 days
Reading time points: 24, 48 and 72 h and 7 days - Number of animals:
- 2 (1 male, 1 female)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: not reversible within 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: not reversible within 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks:
- within 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- other: not reversible within 7 days
- Other effects:
- The test material was highly irritating on rabbit skin (ear) when applied at a dose level of 500 mg. Either scab formation or necrosis was oberved.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Executive summary:
In this early and limited study the compound was concluded to be corrosive after 24 h of exposure to the skin with effects not reversible after a recovery time of 7 days.
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