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EC number: 290-370-1 | CAS number: 90131-58-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Thuya occidentalis, Pinaceae.
Based on a weight of evidence approach, the acute toxicity oral of this UVCB substance can be estimated using adequate toxicity data of major constituents, greater than 10% in the mixture. Three constituents were considered, representing 72% of the mixture.
The acute toxicity oral was estimated using the following additivity formula, as recommended in the section 18.104.22.168.2.3 of the Regulation (EC) No 1272/2008 (CLP) :
100 -(∑ C unknown if > 10%) / ATE mix = ∑ (Ci / ATE i)
Where,Ci = concentration of component i (weight percentage);
i = the individual ingredient from 1 to n ;
n = the number of ingredient
ATE i = acute toxicity estimate of ingredient i
ATE mix = acute toxicity estimate of mixture
DL50 oral of the thuya occidentalis oil is estimated at 229 mg/kg bw.
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