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EC number: 221-312-5 | CAS number: 3064-73-1
In an acute oral toxicity study (17/053-001P), Crl:WI Wistar female rats (3/dose) were given TiBTD (97%) in 1% methyl cellulose at doses of 2000 mg/kg bw and observed for 14 days.
LD50 (female): was >2000 mg/kg bw.
Initially, 3 females were treated at a dose level of 2000 mg/kg bw. As no mortality was observed, a confirmatory group of 3 females was treated at the same dose level. TiBTD did not cause mortality at a dose level of 2000 mg/kg bw in any animal. All animals were symptom-free during the observation period at a dose level of 2000 mg/kg bw. Body weight gains of TiBTD treated animals during the study showed no indication of a test item-related effect. There was no evidence of the macroscopic observations in animals dosed at 2000 mg/kg bw and subjected to the necropsy on Day 14.
This acute oral study is classified as acceptable. It does satisfy the guideline requirement for an acute oral study (OECD 423) in the rat.
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