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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From July 13, 2017 to August 01, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
4.01 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
25 g/L
Incubation duration:
72 h
Temp.:
20 °C
pH:
6.3
Details on results:
Experiment I: at a concentration of 100 mg /20 mL a cloudy mixture was observed.

Experiment II – column elution method:

The concentrations of the different test solutions were calculated automatically using the equation of calibration curve.

Incubation time [hours]

Average [µg/100 mL]

24

437.1

48

383.0

72

383.0

 

Conclusions:
Under the study conditions, water solubility of the test substance was established at 4.01 mg/L at 20 °C.
Executive summary:

A study was conducted to determine the solubility of the test substance according to OECD Guideline 105. Two experiments were carried out using flask method and column elution method. Under the study conditions, water solubility of the test substance was established at 4.01 mg/L at 20 °C (Seiler, 2017).

Description of key information

The water solubility was determined according to OECD Guideline 105 (Seiler, 2017).

Key value for chemical safety assessment

Water solubility:
4.01 mg/L
at the temperature of:
20 °C

Additional information