Registration Dossier
Registration Dossier
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EC number: 208-867-9 | CAS number: 544-31-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 13, 2017 to August 01, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 4.01 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 25 g/L
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 6.3
- Details on results:
- Experiment I: at a concentration of 100 mg /20 mL a cloudy mixture was observed.
- Conclusions:
- Under the study conditions, water solubility of the test substance was established at 4.01 mg/L at 20 °C.
- Executive summary:
A study was conducted to determine the solubility of the test substance according to OECD Guideline 105. Two experiments were carried out using flask method and column elution method. Under the study conditions, water solubility of the test substance was established at 4.01 mg/L at 20 °C (Seiler, 2017).
Reference
Experiment II – column elution method:
The concentrations of the different test solutions were calculated automatically using the equation of calibration curve.
Incubation time [hours] |
Average [µg/100 mL] |
24 |
437.1 |
48 |
383.0 |
72 |
383.0 |
Description of key information
The water solubility was determined according to OECD Guideline 105 (Seiler, 2017).
Key value for chemical safety assessment
- Water solubility:
- 4.01 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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