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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1953
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1953
Report date:
1953

Materials and methods

Principles of method if other than guideline:
Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[bis(2-ethylhexyl)amino]ethanol
EC Number:
202-912-6
EC Name:
2-[bis(2-ethylhexyl)amino]ethanol
Cas Number:
101-07-5
Molecular formula:
C18H39NO
IUPAC Name:
2-[bis(2-ethylhexyl)amino]ethan-1-ol
Specific details on test material used for the study:
A sample of di (2-ethylhexyl) ethanolamine (S-5223) was received from S. Charleston on 11-12-52 for toxicological assay.

Test animals

Species:
rat
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
Substantially saturated vapor
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
Animals observed for 14 days.

Results and discussion

Mortality:
None.
Clinical signs:
other: Slight irritation of extremities.

Applicant's summary and conclusion

Conclusions:
Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical caused no mortality among 6 adult male rats exposed for 8 hours and observed subsequently for a total of 14 days. The only notable response was slight irritiation of extremities.
Executive summary:

Substantially saturated vapor, generated at room temperature by passing air at 2.5 liters/minute through a fritted glass disc immersed in 50 ml of chemical caused no mortality among 6 adult male rats exposed for 8 hours and observed subsequently for a total of 14 days. The only notable response was slight irritiation of extremities.