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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
0.33
Temp.:
25 °C
pH:
7

In order to determine the log Pow of the test substance, the measured Log k 'values of the test substances were applied against the log Pow values.

The regression lines obtained thereby have the function:

1) Eluent water / methanol:

      log Pow 1,446 * log k'+ 0,218

From this a log Pow of the test substance of 0,23 results.

2) Eluent buffer / methanol:

      log Pow 1,427 * log k'+ 0,241

From this a log Pow of the test substance of 0,33 results.

The partition coefficient log Pow of the test substance is 0.23 (measured against water/methanol) or 0,33 (measured against buffer pH7/Methanol).

Conclusions:
The log Kow of the test substance is 0.33 at 25°C at pH 7.0.
Executive summary:

The partition coefficient of the test substance was measured in accordance with OECD Guideline 117. The partition coefficient of the test substance is 0.33 at 25°C at pH 7.0. 

Description of key information

OECD Guideline 117

Key value for chemical safety assessment

Log Kow (Log Pow):
0.33
at the temperature of:
25 °C

Additional information