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EC number: 239-717-0 | CAS number: 15647-11-7
table of results see under attached background material
The test item was applied once to 4 dose-groups of rats (5 male and 5 female Sprague Dawley rats per dose-group) in doses of 1.6 / 2.0 / 2.5 / 3.2 ml/kg bw of undiluted test item. Control animals was applied once to 4.0 ml aqua dest/kg bw.
The observation period was 14 days.
In all doses groups a increase of locomotive behaviour, piloerection, sedation, in higher dose groups also increasing gnawing was observed beginning 1 h after dosing and lasting 24 hours.
At the highest dose (3.2 ml/kg bw) all animals died within 24 hours after oral application of the test item. Necroscopy findings were moderate hyperemia, congestion of liver, reddening of stomach and bloody intestinal mucosa. There were no findings at the end of post exposure period.
According to this study the LD50 value (oral) was determined to be 2.1 ml/kg bw in rats for the test item
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