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Subchronic inhalation study:

Histopathological changes were confined to the nasal passages and larynges of rats exposed to 15 ppm. The changes comprised epithelial inflammatory, atrophic and metaplastic changes seen in the dorsal meatus and dorsal central septum of the nasal passages and, to a lesser degree, in the larynges. These changes are consistent with the inhalation of an irritant substance. Clear signs of repair and recovery of the above changes were seen in rats killed following the 4-week recovery period.

Key value for chemical safety assessment

Mode of Action Analysis / Human Relevance Framework

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