Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
January 2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report date:
2000

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
rel-(3R,3aS,7S,8aS)-3,6,8,8-tetramethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-methanoazulene
Cas Number:
22567-43-7
Molecular formula:
C15H24
IUPAC Name:
rel-(3R,3aS,7S,8aS)-3,6,8,8-tetramethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-methanoazulene
Constituent 2
Chemical structure
Reference substance name:
rel-(3R,3aR,7R,8aS)-3,8,8-trimethyl-6-methyleneoctahydro-1H-3a,7-methanoazulene
Cas Number:
1404220-60-5
Molecular formula:
C15H24
IUPAC Name:
rel-(3R,3aR,7R,8aS)-3,8,8-trimethyl-6-methyleneoctahydro-1H-3a,7-methanoazulene
Constituent 3
Chemical structure
Reference substance name:
rel-(3R,3aS,7S,8aS)-3,8,8-trimethyl-6-methyleneoctahydro-1H-3a,7-methanoazulene
Cas Number:
65450-98-8
Molecular formula:
C15H24
IUPAC Name:
rel-(3R,3aS,7S,8aS)-3,8,8-trimethyl-6-methyleneoctahydro-1H-3a,7-methanoazulene
Constituent 4
Chemical structure
Reference substance name:
rel-(1R,9S,E)-4,11,11-trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene
Cas Number:
17627-40-6
Molecular formula:
C15H24
IUPAC Name:
rel-(1R,9S,E)-4,11,11-trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene
Constituent 5
Chemical structure
Reference substance name:
rel-(1aR,4aR,8aR)-2,4a,8,8-tetramethyl-1,1a,4,4a,5,6,7,8-octahydrocyclopropa[d]naphthalene
Cas Number:
32435-95-3
Molecular formula:
C15H24
IUPAC Name:
rel-(1aR,4aR,8aR)-2,4a,8,8-tetramethyl-1,1a,4,4a,5,6,7,8-octahydrocyclopropa[d]naphthalene
Constituent 6
Chemical structure
Reference substance name:
1,8-dimethyl-4-(propan-2-ylidene)spiro[4.5]dec-7-ene
Molecular formula:
C15H24
IUPAC Name:
1,8-dimethyl-4-(propan-2-ylidene)spiro[4.5]dec-7-ene
Constituent 7
Chemical structure
Reference substance name:
1-methyl-4-(1,2,2-trimethylcyclopentyl)benzene
Cas Number:
51773-81-0
Molecular formula:
C15H22
IUPAC Name:
1-methyl-4-(1,2,2-trimethylcyclopentyl)benzene
Test material form:
liquid
Details on test material:
UVCB
Specific details on test material used for the study:
Batch 9000343808

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
4 hrs
Observation period:
1, 24, 48 and 72 hours and 7, 14 days after application.
Number of animals:
3 (one male and two females)
Details on study design:
The primary irritation score was calculated to reflect and classify the irritant potential of the test article.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: Primary Irritation Score
Score:
3.44
Max. score:
8
Reversibility:
fully reversible within: 14d
Remarks on result:
positive indication of irritation
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
positive indication of irritation
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Remarks on result:
positive indication of irritation

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Executive summary:

Application of Cedrene Washed to healthy intact rabbit skin resulted in a primary irritation score of 3.44.

Therefore Cedrene Washed is considered to be "Irritating" to rabbit skin.