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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: OSHA toxicity screening test. Limited documentation of the study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Guideline:
other: OSHA Toxicity Screening Test
GLP compliance:
no
Test type:
other: saturated atmosphere
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Albino
Details on test animals and environmental conditions:
Average body weight: 190 grams

Administration / exposure

Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: inhalation chamber
- Exposure chamber volume: 325 liter
- Source and rate of air: Air flow- thru generator, 9.9 L/min at 29.92 mm Hg
- Temperature: 25 °C
Time allotted for equilibrium: 161 min



Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
1 h
Concentrations:
Average nominal concentration = 0.9 mg/L air
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
> 0.9 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
1 h
Mortality:
No deaths.
Clinical signs:
other: No untoward behavioral reactions.
Body weight:
The average body weight gain was 52 grams.
Gross pathology:
Necropsy examinations revealed no gross pathologicc alterations.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In an acute inhalation toxicity study on Isodecyl methacrylate with Albino Rats, no signs of toxicity were observed within a 14 day observation period after one-hour exposure to a saturated atmosphere (0.9 mg/L) at 35 °C.
Executive summary:

In an OSHA toxicity screening test in Albino rats on acute inhalation toxicity with Isodecyl methacrylate, no mortalities, behavioral abnormalities or gross pathologic alterations were observed after one hour exposure within a 14 day observation period.

The determined LC0 was > 0.9 mg/L at 35 °C (saturated atmosphere).

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