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Short-term toxicity to fish

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The acute toxicity of the test item C9-11 Methacrylate to fish (zebrafish) was determined according to the OECD Guideline for Testing of Chemicals No. 203 (1992) and EU Council Regulation No. 440/2008/C.1. The test item is a colorless, clear liquid. A water solubility of 40 μg/L ± 20 μg/L at 20 °C ± 0.5 °C was determined. Since the test item is a mixture and in view of the difficulties associated with the evaluation of aquatic toxicity of poorly water soluble test items, a modification of the standard method for the preparation of aqueous media was performed. An approach endorsed by several important regulatory authorities in the EU and elsewhere (ECETOC 1996 and OECD Series No. 23 (2000)), is to expose the organisms to a Water Accommodated Fraction (WAF) of the test item in cases where the test item is a complex mixture and is poorly soluble in water and in the permitted solvents (as defined in the guidelines mentioned above). A semi-static test with daily renewal of the test media was performed with one loading as given above. Seven test organisms were exposed to the WAF treatment and the control for 96 hours. The water quality parameters pH-value, temperature and oxygen saturation, measured after 0, 24, 48, 72 and 96 h, were within the acceptable limits. In this study C9-11 Methacrylate was found to cause no lethal effects to zebrafish after 96 hours at a nominal loading of 100 mg/L. The LL50 after 96 hours was > 100 mg test item/L. The LL0 and LL100 after 96 hours were >=100 and >100 mg test item/L (nominal test item loading), respectively.

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