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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
GLP compliance:
yes (incl. QA statement)
Test type:
fixed dose procedure

Test material

Specific details on test material used for the study:
Identification: TMP-Ketal
Description: clear colourless liquid
Bach number: DEG 1003554

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
No. of animals per sex per dose:
One rat treated at dose of 300 mg/kg bw
Five rats treated at dose of 2000 mg/kg bw

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
discriminating dose
Effect level:
2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
No effect
Clinical signs:
other: No effect
Gross pathology:
No effect

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral toxicity of TMP Ketal in rats was investigated according to the Guideline OECD 420. No effect was found at dose of 2000 mg/kg bw. The LD50 > 2000 mg/kg bw was obtained.
Executive summary:

The acute oral toxicity of TMP Ketal in rats was investigated according to the Guideline OECD 420. No effect was found at dose of 2000 mg/kg bw. The LD50 > 2000 mg/kg bw was obtained.