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EC number: 228-565-0 | CAS number: 6295-57-4
In order to evaluate the irritant/corrosive potential of the test substance to the skin an in vivo test in rabbits was performed in 1985 which was in accordance to guideline OECD 404. 24 hours prior to treatment the animals back was shaved to receive a skin area of about 10 x10 square centimeters for treatment. Only animals with intact skin were chosen for the test. The 6 animals were each treated with 0.5 g test substance per animal on the right flank, whereas the left side serves as control. The treated area was covered by an occlusive bandage and fixed with a non-irritant tape for 4 hours. After these 4 hours, the bandage was removed and the skin washed with lukewarm water to remove remaining test substance. Mortality and clinical signs of toxicity were observed once daily. The skin was assessed for edema, eschar formation or erythema according to Draize, 60 minutes, 24, 48 and 72 hours after removing of bandage. No mortality occurred. No clinical signs of toxicity were observed. The overall mean scoring value is 0 for erythema and edema formation.
Under the conditions of this test and the results obtained, it is concluded, that the test substance is not irritant to the skin.
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