Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-460-3 | CAS number: 27441-70-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 11 to 15, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Reason / purpose for cross-reference:
- reference to other study
- Remarks:
- validated analytical method
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- adopted July 27, 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- March 19, 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 53.4 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 - 72 h
- Temp.:
- 20 °C
- pH:
- 6.9
- Details on results:
- The mean of water solubility was determined to be 0.0534 g/l.
PRELIMINARY TEST
The solubility of the test item was approximately 0.2 g/l applying visual inspection, therefore the shake-flask method has been chosen for the main test. - Conclusions:
- Water solubility: 53.4 mg/l at 20 °C anmd pH 6.9
- Executive summary:
The water solubility of the test item was determined in accordante with the method and procedures outlined into the OECD guideline 105.
A preliminary test for solubility was carried out for the decision whether the column elution method or the flask method has to be used for the performance of the main test. The solubility of the test item was higher than 10 mg/l. Therefore, the flask method was used for the main test.
The concentration in the clear aqueous phase was determined by HPLC-UV validate method. The pH of each sample was recorded.
The mean of water solubility was determined to be 0.0534 ± 0.001 g/l at 20 °C and pH 6.92.
Conclusion
Water solubility: 53.4 mg/l at 20 °C anmd pH 6.9
Reference
Results of the determination of test item concentrations
| Shaking period, day | Measured concentration of test item (g/l ) | Measured pH | |
| Test vessel | Mean | ||
| 1 | 0.0544 | 0.0549 | 7.02 |
| 0.0543 | 7.01 | ||
| 0.0559 | 7.01 | ||
| 2 | 0.0534 | 0.0529 | 6.91 |
| 0.0525 | 6.92 | ||
| 0.0527 | 6.92 | ||
| 3 | 0.0544 | 0.0525 | 6.82 |
| 0.0519 | 6.82 | ||
| 0.0511 | 6.81 | ||
| Mean | 0.0534 (± 0.001) | - | 6.92 |
| (95% confidence interval) | |||
Description of key information
53.4 mg/l at 20 °C anmd pH 6.9
Key value for chemical safety assessment
- Water solubility:
- 53.4 mg/L
- at the temperature of:
- 20 °C
Additional information
OECD 105 - Flask method
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
