Sodium 2-[[4-[3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]phenyl]sulphonyl]ethanesulphonate

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May 02, 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

adopted July 27, 1995

Deviations:

no

Guideline:

other: OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)

Version / remarks:

adopted May 12, 1981

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

The test item was used in its initial form.

Melting / freezing pt.:

290 - 310 °C

Decomposition:

yes

Decomp. temp.:

ca. 310 °C

Before the test the appearance of the test item was yellow powder, after the experiments the test item melted and blackened in the crucible and became smelly.

Replicate	Sample weight [mg]	Loss of Mass of the Sample (%)	Onset of effect [°C]	Endset of effect [°C]	Left Limit [°C]	Right Limit [°C]	Energy [J/g]
Rep 1	2.80	61.1	309.09	316.63	309.09	326.23	-51.77 (exo)
Rep 2	2.93	63.8	310.02	316.58	310.01	326.10	-48.90 (exo)
Mean					309.55	326.17	-50.34

During the heating the test item shows endothermic signals up to 170 °C which can be associated with the evaporation of impurities.

Approximately between 290 – 310 °C an overlapping endotherm peak was observed which could be considered as a first partial melting of a test item followed by an immediate decomposition.

Temperature range [°C]	Sample weight [mg]	Loss of Mass (%)	Observation
25 – 160	3.39	9.7	yellow powder
25 – 310	3.85	19.7	black clumped powder
25 – 360	1.65	51.5	black melt

Conclusions:

The substance undergoes first partial melting, followed by an immediate decomposition at ca 290 - 310 °C.

Executive summary:

The thermal behaviour of the test item was investigated by Differential Scanning Calorimetry method, according to the OECD guidelines 102 and 113. A small amount of test item placed in aluminum cosed crucible and inserted into the furnace of the DSC device. The temperature was increased from 25 to 500 °C with 10 °C/minutes heating rate. The measurement was performed under nitrogen atmosphere. The experiment was performed in duplicate.

A supplementary test was run, in order to clarify the substance thermal behavior. A small amount of test item was weighed into a one-way 40 µl aluminum crucible and sealed with closed aluminum lid using a capsule presser. Thus, the prepared capsule was inserted into the furnace of the DSC device and heated from 25 up to 165 °C, 310 °C and 360 °C with 10 °C/minutes heating rate, than cooled down to 25 °C. Before and after the test, the weight and the appearance of the samples were determined.

During the heating the test item shows endothermic signals up to 170 °C which can be associated with the evaporation of impurities.

Approximately between 290 – 310 °C an overlapping endotherm peak was observed which could be considered as a first partial melting of a test item followed by an immediate decomposition.

Conclusion

The substance undergoes first partial melting, followed by an immediate decomposition at ca 290 - 310 °C.

Description of key information

The substance undergoes first partial melting, followed by an immediate decomposition at ca 290 - 310 °C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

290 °C

Additional information

OECD 102/113 - Differential Scanning Calorimetry method