Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference
Reference Type:
other: prediction
Title:
QSAR prediction of levonorgestrel acetate
Author:
Gedeon Richter Plc.
Year:
2016
Bibliographic source:
QSAR Toolbox

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
QSAR

Test material

Constituent 1
Chemical structure
Reference substance name:
(17β)-13-Ethyl-17-ethynyl-3-oxogon-4-en-17-yl acetate
EC Number:
604-013-8
Cas Number:
13732-69-9
Molecular formula:
C23H30O3
IUPAC Name:
(17β)-13-Ethyl-17-ethynyl-3-oxogon-4-en-17-yl acetate

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium TA 1535
Metabolic activation:
with and without
Species / strain:
S. typhimurium TA 1537
Metabolic activation:
with and without
Species / strain:
S. typhimurium TA 97
Metabolic activation:
with and without
Species / strain:
S. typhimurium TA 100
Metabolic activation:
with and without
Remarks on result:
no mutagenic potential (based on QSAR/QSPR prediction)

Applicant's summary and conclusion