Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 July 2016 - 05 January 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
2-bromobutane
EC Number:
201-140-7
EC Name:
2-bromobutane
Cas Number:
78-76-2
Molecular formula:
C4H9Br
IUPAC Name:
2-bromobutane
Test material form:
liquid
Details on test material:
- Name of test material (as cited in the report): JNJ-47961173-AAA
- Physical state: Liquid
- Colour: Colourless
Specific details on test material used for the study:
- Batch n°: M15IB3251
- Analytical purity: 100% (based on gas chromotographic purity)
- Expiration date: 7 April 2017
- Storage condition: At room temperature

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
< -80 °C
Atm. press.:
1 013.25 hPa
Decomposition:
no

Any other information on results incl. tables

Preliminary test

From the TGA curve it could be derived that the weight of the sample decreased significantly from the start. At 73°C the sample weight has decreased by 25%. After the experiment it was observed that the test item was evaporated from the sample container.

Main tests

The test item did not crystallize during cooling. During heating an endothermic peak between 25°C and 125°C was observed. The extrapolated onset temperature of the peak was 89.997°C. This effect was most likely obtained due to boiling of the test item. After the experiment it was observed that the test item was evaporated from the sample container.

To further investigate the melting temperature of the test item, two subsamples of the test item were stored for 19 hours at -23.6 ± 0.6°C and at -82.2 ± 2.4°C respectively. It was observed after storage that the test item was a liquid (-20°C and -80°C freezer). According to this it was concluded that the melting temperature of the test item is < -80°C (< 193K).

Applicant's summary and conclusion

Conclusions:
The melting temperature of JNJ-47961173-AAA (2-bromobutane) was determined to be < -80.0°C (< 193.2K) by applying a storage experiment in the freezer.