Registration Dossier
Registration Dossier
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EC number: 603-912-2 | CAS number: 135266-72-7
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Data source
Reference
- Reference Type:
- other: prediction
- Title:
- QSAR prediction of cis diester
- Author:
- Gedeon Richter Plc.
- Year:
- 2 016
- Bibliographic source:
- QSAR Toolbox
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- QSAR
Test material
- Reference substance name:
- (-)-1β-2(2´-Diethoxy-carbonyl-ethyl)-1α-ethyl-1,2,3,4,6,7,12,12b-α-octahydro-indolo[2,3-a]quinolizin
- EC Number:
- 603-912-2
- Cas Number:
- 135266-72-7
- Molecular formula:
- C25H34N2O4
- IUPAC Name:
- (-)-1β-2(2´-Diethoxy-carbonyl-ethyl)-1α-ethyl-1,2,3,4,6,7,12,12b-α-octahydro-indolo[2,3-a]quinolizin
Constituent 1
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 76 mg/kg bw/day (nominal)
- Remarks on result:
- other: prediction
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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