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EC number: 947-340-4
CAS number: -
Analytical Determinations Part1
Nominal Concentration in mg/L
Measured Concentration in mg/L
Geometric Mean in mg/L
oM old Medium nM new Medium
Analytical Determinations Part2
%Nominal concentration after 0h
%Nominal concentration after 48h nM
The acute toxicity of Ukanol FR 70 against Danio rerio Hamilton Buchanan
was determined following EU-Method C.1 resp. OECD Guideline 203.
The main study was performed as semi-static limit test using a
concentration of 1.6 mg/L, representing the maximal solubility in test
medium. The maximal solubility in test medium was determined during
validation of the analytical method. Acetone was used as solvent to
prepare the test solutions at the limit of solubility. Seven fish were
exposed to the test item for 96 hours. After 48 hours the test medium
was renewed. In the solvent control and in the treatment no significant
mortality was observed. The pH and the oxygen value of the water were
normal. During validation of the analytical method, the test item had
shown insufficient stability. The recovery after four days had been 68.2
%. Therefore, the study was performed under semi-static conditions. The
content of the test item in the test solutions was determined at the
beginning and at the end of the test and after 48 h before and after
medium renewal using HPLC. The correlation between nominal and measured
concentration in the freshly prepared test solution was good (85 % after
0 hours and 99 % after 48 h). The recovery of measured start
concentration was 38 % after 48 hours and 29 % after 96 hours. The
unexpectedly poor recovery means that the characteristic of the test
medium in presence of the animals is not identical with the medium
without fish, used during validation of the analytical method. Without
much doubt, the loss of test item was caused by ingestion by the fish or
adsorption on to the animals or the excrements of the animals.
The following results for the test item Ukanol FR 70 could be determined:
96h NOEC ≥ 0.85 mg/L (geometric mean)
96h LC50 > 0.85 mg/L (geometric mean)
96h NOEC ≥ 1.6 mg/L (nominal)
96h LC50 > 1.6 mg/L (nominal)
For risk assessment purposes a NOEC value of 1.6 mg/l (nominal) will be
used based on loss of the test substance in the test medium.
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