Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The substance is included in the training set of a skin sensitisation QSAR but it is unclear what the source of this endpoint is.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1994

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Based on these references:
Magnusson, B. and Kligrnan, A.M. (1969). The identification of contact allergens by animal assay. The guinea pig maximization test. J. Invest. Dermat. 52,268-276.
Goodwin, B.F.J. and Johnson, A.W. (1985). Single injection adjuvant test. Curr. Prob. Dermatol. 14,201-207.
GLP compliance:
no
Type of study:
guinea pig maximisation test

Test material

Constituent 1
Chemical structure
Reference substance name:
4-hydroxy-3,5-dimethoxybenzaldehyde
EC Number:
205-167-5
EC Name:
4-hydroxy-3,5-dimethoxybenzaldehyde
Cas Number:
134-96-3
Molecular formula:
C9H10O4
IUPAC Name:
4-hydroxy-3,5-dimethoxybenzaldehyde
Test material form:
not specified
Details on test material:
Solved in Ethanol. Source: Sigma Chemical Co.

In vivo test system

Test animals

Species:
guinea pig
Details on test animals and environmental conditions:
No more details specified

Results and discussion

In vivo (non-LLNA)

Results
Key result
Remarks on result:
positive indication of skin sensitisation
Remarks:
Only the conclusion of the test is reported

Applicant's summary and conclusion

Conclusions:
Syringaldehyde was found to be a strong skin sensitizer using the guinea pig maximisation test.