Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 Sep 2017 - 24 Nov 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Decomposition temp.: 200°C

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
>= 0.029 - <= 0.69 Pa
Key result
Temp.:
25 °C
Vapour pressure:
>= 0.043 - <= 0.85 Pa

Any other information on results incl. tables

Table: Results of the isothermal TGA analysis (test item)

Experiment

Temperature [°C]

Weight loss [µg/min]

νT

[g/cm2/h]

log νT

log PT

PT[Pa]

1

160

18.0670

2.16x10-3

-2.67

1.72

53

 

170

21.9934

2.63x10-3

-2.58

1.83

68

 

180

25.6485

3.06x10-3

-2.51

1.92

83

2

160

14.2524

1.70x10-3

-2.77

1.59

39

 

170

16.4149

1.96x10-3

-2.71

1.67

47

 

180

19.0748

2.28x10-3

-2.64

1.75

57

3

160

15.4001

1.84x10-3

-2.74

1.64

43

 

170

20.2238

2.41x10-3

-2.62

1.79

61

 

180

26.0817

3.11x10-3

-2.51

1.93

85

Using the results of Experiment 1 and Experiment 2, the curve of log PT of the test item as function of the reciprocal temperature had a coefficient of correlation <0.99. Therefore, a third experiment was performed. Coefficient of correlation using the results of Experiment 1 and Experiment 3 was <0.99. Coefficient of correlation using the results of Experiment 2 and Experiment 3 was <0.99. Since the test item is a mixture (UVCB), it was decided to report a range for the vapour pressure using the plot of the log PT of the test item as function of the reciprocal temperatures for each individual experiment. 

Experiment 1:  log PT= -1913 x1/T + 6.14 (r = 0.998, n = 3). 

Experiment 2:  log PT= -1589 x 1/T + 5.26 (r = 0.9995, n = 3). 

Experiment 3:  log PT= -2875 x 1/T + 8.27 (r = 0.9999, n = 3).

Plots: see attached background material.

 

Table: Vapour pressure results

Experiment 1

Temperature [°C]

 

log PT

PT [Pa]

20

 

-0.38

0.41

25

 

-0.27

0.53

  

Experiment 2

 

Temperature [°C]

 

log PT

PT [Pa]

20

 

-0.16

0.69

25

 

-0.07

0.85

 

Experiment 3

Temperature [°C]

 

log PT

PT [Pa]

20

 

-1.53

2.9E-2

25

 

-1.37

4.3E-2

 

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the substance at 20°C was determined to be in the range from 2.9E-2 to 0.69 Pa.
The vapour pressure of the substance at 25°C was determined to be in the range from 4.3E-2 to 0.85 Pa.
Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950.

From the measured weight losses in the temperature range 160 -180°C, the vapour pressure of the substance was determined. Three experiments were performed. Because of the relatively large differences between the results, the vapour pressure of the substance was determined from each of the three vapour pressure regression curves. The vapour pressure of the substance was reported as a range. The vapour pressure of the substance at 20°C was determined to be in the range from 2.9E-2 to 0.69 Pa. The vapour pressure of the substance at 25°C was determined to be in the range from 4.3E-2 to 0.85 Pa.

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