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EC number: 281-638-9 | CAS number: 84000-82-8
Ames assay was performed to determine the mutagenic nature of N-methyl-2-pyrrolodone. The study was performed as per the method described by Ames et al using Salmonella typhimurium TA97, TA98, TA100, TA102, TA104, TA2638 and UTH8413 and UTH8414 with and without S9 metabolic activation system. The test chemical was dissolved in sterile double distilled water depending on solubility and at dose levels of0, 0.01, 0.1, 1.0, 10.0, 100.0 or 1000.0µmol/plate. Concurrent solvent and positive control chemicals were included in the study. The plates were observed for a dose dependent and a 2-fold increase in the number of revertants/plate. All assay procedures were performed under yellow light to avoid photodynamic effects. N-methyl-2-pyrrolodonedid not induce gene mutation in Salmonella typhimurium TA97, TA98, TA100, TA102, TA104, TA2638 and UTH8413 and UTH8414 in the presence and absence of S9 metabolic activation system and hence it is not likely to classify as a gene mutant in vitro.
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