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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 June 2016 to 01 July 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
> 1 076 g/L
Conc. based on:
test mat.
Incubation duration:
48 h
Temp.:
20 °C
pH:
0.5
Water solubility:
> 1 100 g/L
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
20 °C
pH:
0.5
Water solubility:
> 1 188 g/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
0.5
Details on results:
Preliminary test
The test item was dissolved immediately after addition of water. The preliminary visual experiments showed that the water solubility of the test item is > 10 mg/L.

Flask method
After the equilibration time no precipitate was observed in the flasks. As the test item was dissolved completely no further analytical determination was performed. The water solubility of the test item at 20 °C was determined to be > 1076 g/L.

Table1: Results of the preliminary visual estimation of the water solubility

Amount of test item

/ mg

Added volume of dist. water

/ mL

Total volume

/ mL

Appearance of mixture

105.8

0.1

0.1

dissolved

Table2: Water solubility experiments of the test item

Experiment

24 h experiment

48 h experiment

72 h experiment

Blank

experiment (72 h)

Amount of test item / g

11.0

10.8

11.9

-

Amount of demineralized water / ml

10

10

10

10

Stirring time at 30 °C / h

24

48

72

72

pH at 23 - 24 °C

0.5

0.5

0.5

5.8

Water solubility / g/L

> 1100

> 1076

> 1188

-

Conclusions:
The water solubility of the test item Tetrachlorogold(III) acid hydrate at a temperature of 20 °C was determined to be > 1076 g/L.
Executive summary:

The water solubility of the test item tetrachlorogold(III) acid hydrateat a temperature of 20 °C was determined according to the OECD 105 and EU A.6 guidelines (Winkler 2016). This study is reliable without restrictions as it is GLP-compliant and was conducted according to standard guidelines.

The preliminary visual experiments showed that the water solubility of the test item is > 10 mg/L, therefore the main test was conducted using the flask method. In the main test, no precipitate was observed in the flasks after the equilibration time. As the test item was dissolved completely no further analytical determination was performed. The water solubility was calculated from the initial weight. The water solubility of the test item at 20 °C was determined to be > 1076 g/L.

Description of key information

Tetrachloroauric acid is very soluble in water. The water solubility of the test item at 20 °C is > 1076 g/L.

Key value for chemical safety assessment

Water solubility:
1 076 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item tetrachlorogold(III) acid hydrate at a temperature of 20 °C was determined according to the OECD 105 and A.6 guidelines (Winkler 2016).

The preliminary visual experiments showed that the water solubility of the test item is > 10 mg/L, therefore the main test was conducted using the flask method. In the main test, no precipitate was observed in the flasks after the equilibration time. As the test item was dissolved completely no further analytical determination was performed. The water solubility was calculated from the initial weight. The water solubility of the test item at 20 °C was determined to be > 1076 g/L. This study is reliable without restrictions as it is GLP-compliant and was conducted according to standard guidelines, therefore is suitable for use as a key study for this endpoint.

Information on water solubility is also available from two peer reviewed handbooks (O’Neil 2006, Lide 2008). Although the methods used are not known the handbooks are considered reliable and suitable for use as supporting studies for this endpoint. Both handbooks report the substance to be 'very soluble'.