Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-571-3 | CAS number: 97-30-3
- The intradermal application of the 5 %, 3.5 % and 2 % (w/w) test substance in sesame oil showed medium reactions, but the 0.5 % (w/w) solution of the test substance in sesame oil elicited a slight reaction.
- Dermal application without Duhring Chambers of 100 % and 75 % (w/w) solutions of the test substance in sesame oil showed slight reactions. Dermal application of 50 % and 25 % (w/w) test substance in sesame oil with Duhring Chambers provoked a medium or slight reaction, respectively, whereas the 15 % and 5 % (w/w) test substance in sesame oil with Duhring Chambers showed no reaction.
- Control group: no reactions
- The intradermal and the epicutaneous induction resulted in slight skin reactions in a various number of animals indicating that the chosen test substance concentrations led to slight irritation. In the control group animals no skin reaction was observed after the application of the vehicle sesame oil.
- Additional observations: Crust formation (diameter: 6 mm) was observed at the injection sites with FCA in the test group and the control group animals 1-2 weeks following the intradermal injection.
- No visible changes of the treated skin sites were observed in the test group animals 24 h and 48 h after patch removal (= grading "0").
- In the control group animals also no visible signs of skin reactions were observed (= grading "0") indicating that the chosen concentration of the test substance was a subirritative dose.
In a dermal sensitization study according to OECD guideline 406 with Isostearic acid, esters with methyl α-D-glucoside (100% UVCB substance), Dunkin-Hartley guinea pigs were tested using the method of Magnusson and Kligman. Positive control substance was 2-Mercaptobenzothiazole.
Based on the results of the pilot study, for the intradermal and epicutaneous induction procedure test substance concentrations of 0.5 % and 75 % in sesame oil were used, respectively. The test article concentration for the challenge procedure was 15 % in sesame oil.
Slight skin reactions were observed after induction, whereas at challenge no visible changes of the treated skin sites (no erythema and no edema) were observed in test or control animals at any time point.
In this study Isostearic acid, esters with methyl α-D-glucoside is not a dermal sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again