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Physical & Chemical properties

Stability in organic solvents and identity of relevant degradation products

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Administrative data

Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report Date:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: European Commission: Guidance for Generating and Reporting Methods of Analysis in Support of Pre-Registration Data Requirements for Annex II (Part A, section 4) and Annex III (Part A, section 5) of Directive 91/414, SANCO/3029/99 rev. 4 (11/07/00).
Deviations:
no
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Test substance stable:
yes
Transformation products:
no

Any other information on results incl. tables

In the frame of the validation of an analytical method conducted according to the European Commission: Guidance for Generating and Reporting Methods of Analysis in Support of Pre-Registration Data Requirements for Annex II (Part A, section 4) and Annex III (Part A, section 5) of Directive 91/414, SANCO/3029/99 rev. 4 (11/07/00) the stability of the test substance was investigated. Stock solutions of the test substance were prepared in methanol at concentrations of 915 - 2320 mg/l. In order to dissolve the test substance the solutions were ultrasonicated for 10 minutes. The stock solutions were analysed at a nominal concentration of 500 mg/l. Since the coefficient of variation on the response factors of the calibration solutions was = 10% the stock solutions were stable when stored at room temperature for at least 1 day.

Applicant's summary and conclusion

Conclusions:
The test substance dissolved in methanol was stable for at least 1 d.
Executive summary:

In the frame of the validation of an analytical method conducted according to the European Commission: Guidance for Generating and Reporting Methods of Analysis in Support of Pre-Registration Data Requirements for Annex II (Part A, section 4) and Annex III (Part A, section 5) of Directive 91/414, SANCO/3029/99 rev. 4 (11/07/00) the stability of the test substance was investigated. Stock solutions of the test substance were prepared in methanol at concentrations of 915 - 2320 mg/l. In order to dissolve the test substance the solutions were ultrasonicated for 10 minutes. The stock solutions were analysed at a nominal concentration of 500 mg/l. Since the coefficient of variation on the response factors of the calibration solutions was = 10% the stock solutions were stable when stored at room temperature for at least 1 day.