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EC number: 231-335-2 | CAS number: 7493-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June - July 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- No information on purity was given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- No information on purity was given.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Allyl phenoxyacetate
- EC Number:
- 231-335-2
- EC Name:
- Allyl phenoxyacetate
- Cas Number:
- 7493-74-5
- Molecular formula:
- C11H12O3
- IUPAC Name:
- allyl phenoxyacetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 109 - 117 g (males), 103 - 116 g (females)
- Fasting period before study: overnight prior to dosing
- Housing: individually in solid-bottom polypropylene boxes, softwood sawdust was used as bedding material
- Diet: R 4 Alleindiät für Ratten (Ssniff Versuchstier-GmbH, Soest, Germany), ad libitum
- Water: ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 23
- Humidity (%): 40 - 70
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 40% alcohol pure in polyethyleneglycol 200 (v/v)
- Details on oral exposure:
- A range-finding study was carried out to establish a dosing regimen for the main study.
VEHICLE
- Concentration in vehicle: range-finding study: 25, 50, 200 and 500 mg/mL; main study: 50, 63, 79.4 and 100 mg/mL
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- Range-finding study: 250, 500, 2000 and 5000 mg/kg bw
Main study: 500, 630, 794 and 1000 mg/kg bw - No. of animals per sex per dose:
- Range-finding study: 2 males and 2 females
Main study: 5 males and 5 females - Control animals:
- no
- Details on study design:
- Range-finding study:
- Duration of observation period following administration: 7 days
- Frequency of observations: Animals were observed daily during the 7 day period following treatment. Individual body weights were recorded on the day of treatment.
- Necropsy of survivors performed: no
Main study:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed 15 and 30 min and 1, 2 and 4 h after administration and subsequently at least once daily for 14 days. Individual body weights were determined on the day before treatment (Day -1), on the day of treatment (Day 0), at death and again 7 and 14 days after treatment.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- The acute oral median lethal dose LD50 and 95% fiducial limits for combined male and female animals were calculated using probit method (Finney, D.J. (1964), Statistical Methods for Biological Assay, 2nd Edition, London, Charles Griffin).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 835 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 716 - < 974
- Mortality:
- Range-finding study: All animals died at 2000 and 5000 mg/kg bw. No mortality was observed at 250 and 500 mg/kg bw. The mortalities indicated a LD50 in the range of 500 - 2000 mg/kg bw.
Main study: Three males and four females died at 1000 mg/kg bw, one male and 3 females at 794 mg/kg bw and 3 males at 630 mg/kg bw. With exception of one animal which died on Day 4 after treatment, all animals were found dead 4 h up to 2 days after treatment. No mortality occurred at 500 mg/kg bw. - Clinical signs:
- other: The majority of animals showed lacrimation, piloerection, hunched position, oscillated movements and shaggy coat following treatment in all dose level groups. Other occasional signs of intoxication were lethargy at 630 mg/kg bw and higher, eyes half close
- Gross pathology:
- Sacrificed animals:
Thickened areas covering partially the mucosal surface of the forestomach and adhesions:
a) between forestomach and liver
b) between forestomach, liver and spleen
c) between forestomach, liver, spleen and peritoneum
Dead animals:
Macroscopic findings were mainly associated with the gastrointestinal tract. The following toxic abnormalities were observed:
Stomach overloaded, severe reddening of the forestomach, red patches on mucosal surface of corpus and anteum of stomach. Moderate until severe congestion in liver, presence of bloody fluid in thorax and rounded spot of blood on the surface of thyme.
Additional observations were noted in one animal that died 4 days after treatment: false membrane, thickness and red patches in the mucosal surface of the forestomach, slight adhesion between forestomach and spleen and loamy-coloured liver.
Any other information on results incl. tables
Table 1. Results of the acute toxicity study.
Dose level (mg/kg bw) |
Mortalities |
|
Male |
Female |
|
500 |
0/5 |
0/5 |
630 |
3/5 |
0/5 |
794 |
1/5 |
3/5 |
1000 |
3/5 |
4/5 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Acute Tox. Cat. 4 according to Regulation (EC) No 1272/2008
- Conclusions:
- In this acute oral toxicity study a LD50 value of 835 mg/kg bw in male and female rats was calculated according to the method of Finney (1963).
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