Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-aminothiazol-4-acetic acid
EC Number:
249-769-6
EC Name:
2-aminothiazol-4-acetic acid
Cas Number:
29676-71-9
Molecular formula:
C5H6N2O2S
IUPAC Name:
(2-amino-1,3-thiazol-4-yl)acetic acid
Test material form:
solid: particulate/powder

Results and discussion

Water solubility
Water solubility:
1.65 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
5 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
5
Details on results:
Measured results in the 3 seperate flasks were 1649.9, 1645.9 and 1643.8 mg/L with an RSD of 0.19%.There was no evidence of temperature dependance.

Applicant's summary and conclusion

Conclusions:
The water solubility of the substance as determined using the shake-flask method was 1.65 g/L at room temperature (20°C).

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