2-aminothiazol-4-acetic acid

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

2-aminothiazol-4-acetic acid

EC Number:

249-769-6

EC Name:

2-aminothiazol-4-acetic acid

Cas Number:

29676-71-9

Molecular formula:

C5H6N2O2S

IUPAC Name:

(2-amino-1,3-thiazol-4-yl)acetic acid

Test material form:

solid: particulate/powder

Results and discussion

Water solubility

Water solubility:

1.65 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

5 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

5

Details on results:

Measured results in the 3 seperate flasks were 1649.9, 1645.9 and 1643.8 mg/L with an RSD of 0.19%.There was no evidence of temperature dependance.

Applicant's summary and conclusion

Conclusions:

The water solubility of the substance as determined using the shake-flask method was 1.65 g/L at room temperature (20°C).