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Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of particle tested:
other: Not specified
Type of distribution:
mass based distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
2-aminothiazol-4-acetic acid
EC Number:
249-769-6
EC Name:
2-aminothiazol-4-acetic acid
Cas Number:
29676-71-9
Molecular formula:
C5H6N2O2S
IUPAC Name:
(2-amino-1,3-thiazol-4-yl)acetic acid
Test material form:
solid: particulate/powder

Results and discussion

Mass median aerodynamic diameter:
52.174 µm
Geometric standard deviation:
0.035
Particle sizeopen allclose all
Percentile:
D10
Mean:
14.158 µm
St. dev.:
1.93
Percentile:
D50
Mean:
43.615 µm
St. dev.:
0.9
Percentile:
D90
Mean:
111.755 µm
St. dev.:
1.88

Any other information on results incl. tables

Under magnification, the sample appeared to be irregular shaped crystals. The smallest particle size was approximately 3 µm and the largest size approximately 288 µm.

Applicant's summary and conclusion

Conclusions:
The particle size mass media aerodynamic diameter (MMAD) was determined to be 52.174 µM and the volume of sample with particles < 10 µm was 6.44%.