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EC number: 214-183-1 | CAS number: 1111-67-7
Materials and Methods
Copper II sulphate pentahydrate was assayed for mutation in 5-histaidine requiring strains (TA98, TA100, TA1537 and TA102) of Salmonella typhimurium, both in the presence and absence of metabolic activation by Aroclor 1254-induced rat liver post-mitochondrial fraction (S-9) in 2 separate experiments. Following a range finding study, two experiments were carried out with concentrations of 1.6, 8, 40, 200 and 1000 µg/l in experiment one and 50, 100, 200, 400 and 800 µg/l in experiment two. The tests were carried out in triplicate. Both positive and negative controls were included.
The study complied with the following guidelines and was conducted in accordance with GLP:
OECD Guidelines 471 EC Directive 2000/32 Annex V Test B14 UKEMS Guidelines
Results and discussion
None of the dose concentrations in any of the test strains in either the absence or presence of S-9 resulted in an increase in revertant numbers that were statistically significant at the 1% level when analysed using a Dunnett’s test. It was therefore concluded that copper II sulphate pentahydrate was unable to induce mutation in 5 strains of S. typhimurium, when tested at concentrations extending to the toxic range, in both the absence and presence of rat liver metabolic activation system.
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