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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Description of key information

EPA OPP 72-2, OECD Guideline 202, GLP, key study, validity 1:
48h-EC50 (Daphnia magna) = 11.3 mg/L (measured, as main ingredient)
ISO Guideline 14669 (draft 1990), GLP, key study, validity 2:
48h-LC50 (Acartia tonsa) = 0.45 mg/L (nominal, as main ingredient)
In conclusion, THPS is very toxic to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
11.3 mg/L

Marine water invertebrates

Marine water invertebrates
Effect concentration:
0.45 mg/L

Additional information

Eight studies are available to assess the short-term toxicity of the active substance THPS to aquatic invertebrates. These studies were performed on the THPS in solution in static, semi-static or flow-through conditions, with reshwater and marine species. The relevant results were expressed as main ingredient (100% active substance).

 

There are two studies of reliability 1 and 2 on the freshwater species Daphnia magna (Jenkins, 1991c; Douglas, 1985b) and six studies of reliability 1 and 2 on several marine species (Torp, 1994; Altin, 1994; Boeri, 1995b; Boeri, 1995c; Douglas, 1986; Sewell, 2004).

 

For freshwater species Daphnia magna, the study of best reliability and lowest EC50 value has been defined as key study (Jenkins, 1991c).

For marine species, the most sensitive species is Acartia tonsa. Three studies of reliability 2 are available on this species and show similar results (Torp, 1994; Altin, 1994; Sewell, 2004). The study of lowest L(E)C50 value and owned by Rhodia has been defined as key study (Torp, 1994). Even if the LC50 value of this study (=0.45 mg/L) is slightly greater than the LC50 value of the Sewell (2004) study (=0.29 mg/L), we are more confident on the test substance, that should be closer to the reference substance.

Results are expressed in the table below (as main ingredient):

Test method

Species

Endpoint / Type of test

Exposure

Reliability

Flag

Results (L(E)C50 (95% CL), mg/L)

Reference

EPA OPP 72-2 and OECD Guideline 202

Daphnia magna (freshwater species)

Immobilisation / Acute

Static, 48h

1

KS

11.3 (9.1-13.6)

Jenkins, 1991c

OECD Guideline 202

Daphnia magna (freshwater species)

Immobilisation / Acute

Static, 48h

2

SS

14.3 (12.0-16.5)

Douglas, 1985b

ISO 14669 (draft 1990)

Acartia tonsa (marine species)

Mortality / Acute

Static, 48h

2

KS

0.45 (0.38-0.54)

Torp, 1994

ISO 14669 (draft 1990)

Acartia tonsa (marine species)

Mortality / Acute

Static, 48h

2

SS

0.98 (0.83-1.13)

Altin, 1994

ISO 14669 (1999)

Acartia tonsa (marine species)

Mortality / Acute

Static, 48h

2

SS

0.29 (0.23-0.38)

Sewell, 2004*

EPA OPP 72-3

Crassostrea virginica (marine species)

Shell growth / Acute

Flow-through, 96h

1

SS

1.6 (1.3-1.9)

Boeri, 1995b

EPA OPP 72-3

Mysidopsis bahia (marine species)

Mortality, Shell growth / Acute

Flow-through, 96h

1

SS

7.30 (6.03-9.61)

Boeri, 1995c

Ministry of Agriculture, Fisheries and Food, UK

Crangon crangon (marine species)

Mortality / Acute

Semi-static, 96h

2

SS

253 (190-337)

Douglas, 1986

*This study is not owned by Solvay, the test report is available on the US EPA web site at EPA/OPPT/Toxic Substance Control Act Section 8(e), the test substance was not manufactured by Solvay, THPS main ingredient content is 75 %.

According to the key studies, THPS is considered harmful to freshwater species Daphnia magna (48-EC50 = 11.3 mg/L) and very toxic to marine species Acartia tonsa (48h-LC50 = 0.45 mg/L). Therefore, it can be concluded that THPS is very toxic to aquatic invertebrates