Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

OECD Guideline 210, EPA OPPTS 850.1400, GLP, key study, validity 1:
32d-NOEC (Pimephales promelas) = 0.83 mg/L (mean measured, as main ingredient) for larval survival and growth.

(For more details please read CSR available in section 13).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.83 mg/L

Additional information

One key study of reliability 1 is available to assess the long-term toxicity of the active substance THPS to fish. This study was performed on the THPS in solution in flow-through conditions, with the freshwater species Pimephales promelas.

The result of this study is expressed in the table below (as main ingredient):

Test method


Endpoint / Type of test




Result (NOEC, mg/L)


OECD Guideline 210 and EPA OPPTS 850.1400

Pimephales promelas (freshwater species)

Larval survival and growth / Chronic

Flow-through, 32 days




Knight, 2002

In conclusion, the 32d-NOEC on Pimephales promelas was determined to be 0.83 mg/L.