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EC number: 813-543-0 | CAS number: 73984-93-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 January 2018 to 12 January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.036 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6
- Details on results:
- PRELIMINARY RESULTS
- The test material was a liquid. The preliminary test indicated that the test material was soluble at a level of less than 1 g/L.
DEFINITIVE TEST RESULTS
- Samples were taken from the three flasks at two time points: Day 2 and Day 3. Table 1 summarises the analytical measurements from the experiment.
- The between day difference between Day 2 and 3 was less than 15%. No other sampling was required. The amount of test material dissolved in water was 36.33 mg/L. The test temperature was 19.5 ± 0.5°C.
- The test material had a water solubility of 36 mg/L (0.036 g/L) at 20°C as determined by OECD Test No. 105.
OBSERVATIONS
- In the preliminary test, the test material in water is a clear solution with excess test material remaining in white globules adhering to the bottom of the vessel. With vigorous shaking it did break to pieces, but the solution remained clear with the white globules at the bottom of the vessel. - Conclusions:
- Under the conditions of this study the test material had a water solubility of 0.036 g/L at 20.0°C.
- Executive summary:
The water solubility of the test material was determined in accordance with the standardised guideline OECD 105, under GLP conditions using the flask method.
A preliminary test was conducted in order to approximate the amount of test material that would dissolve in water and the time required to reach saturation. The preliminary test indicated that the test material was soluble at a level of less than 1 g/L.
The flask method was used for determination of solubility. Based on the preliminary test results, three containers with lids were prepared containing 7 grams of the test material in 700 mL of water for the definitive test. Containers were placed in a water bath at 20.0 ± 0.1°C with constant orbital shaking at 120 rpm until equilibrium was reached. Equilibrium was determined by two consecutive daily measurements of the dissolved test material being within 15% of each other. An aliquot from each container was collected after Day 2 and 3 for analysis.
The between day difference between Day 2 and 3 was less than 15%. No other sampling was required. The amount of test material dissolved in water was 36.33 mg/L. The test temperature was 19.5 ± 0.5°C.
Under the conditions of this study the test material had a water solubility of 0.036 g/L at 20.0°C.
Reference
Table 1: Results Summary
Sample |
Day 2 (mg/L) |
pH |
Day 3 (mg/L) |
pH |
Sample 1 |
22 |
6 |
28 |
6 |
Sample 2 |
53 |
6 |
57 |
6 |
Sample 3 |
32 |
6 |
26 |
6 |
Timepoint’s Average Test Material Concentration |
35.67 |
|
37.00 |
|
Between Day Average Test Material Concentration |
36.33 mg/L |
|||
Between Day Difference: Relative Percent Difference (RPD)s |
3.67 % |
Description of key information
Under the conditions of the study the test material had a water solubility of 0.036 g/L at 20.0°C.
Key value for chemical safety assessment
- Water solubility:
- 0.036 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was determined in accordance with the standardised guideline OECD 105, under GLP conditions using the flask method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
A preliminary test was conducted in order to approximate the amount of test material that would dissolve in water and the time required to reach saturation. The preliminary test indicated that the test material was soluble at a level of less than 1 g/L.
The flask method was used for determination of solubility. Based on the preliminary test results, three containers with lids were prepared containing 7 grams of the test material in 700 mL of water for the definitive test. Containers were placed in a water bath at 20.0 ± 0.1°C with constant orbital shaking at 120 rpm until equilibrium was reached. Equilibrium was determined by two consecutive daily measurements of the dissolved test material being within 15% of each other. An aliquot from each container was collected after Day 2 and 3 for analysis.
The between day difference between Day 2 and 3 was less than 15%. No other sampling was required. The amount of test material dissolved in water was 36.33 mg/L. The test temperature was 19.5 ± 0.5°C.
Under the conditions of this study the test material had a water solubility of 0.036 g/L at 20.0°C.
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