Registration Dossier
Registration Dossier
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EC number: 271-845-2 | CAS number: 68609-96-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Glycidyloxy Compounds Used in Epoxy Resin Systems: A Toxicology Review
- Author:
- Gardiner Thomas H & al
- Year:
- 1 992
- Bibliographic source:
- REGULATORY TOXICOLOGY AND PHARMACOLOGY 15, S1 -S77 ( 1992)
Materials and methods
Test material
- Reference substance name:
- Oxirane, mono[(C8-10-alkyloxy)methyl] derivs.
- EC Number:
- 271-845-2
- EC Name:
- Oxirane, mono[(C8-10-alkyloxy)methyl] derivs.
- Cas Number:
- 68609-96-1
- Molecular formula:
- C11H22O2, C12H24O2, C13H26O2
- IUPAC Name:
- 2-[(decyloxy)methyl]oxirane; 2-[(octyloxy)methyl]oxirane
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- unchanged (no vehicle)
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- other: diethyl phthalate
- Concentration / amount:
- 20%
Results and discussion
In vivo (non-LLNA)
Results
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- The Epoxy Glycidyl Ether was considered to be a skin sensitizer in a Buehler test.
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